A Histological Study on the Possible Adverse Effect of Sofosbuvir on Lungs of Adult Male Albino Rats

Document Type : Original Article

Authors

Departments of of Histology, Faculty of Medicine, Cairo university, Egypt.

Abstract

Background: In 2011, three new direct-acting antivirals (DAAs) for HCV including sofosbuvir were accredited for HCV
management.
Aim: To evaluate the impact of Sofosbuvir treatment on the histological structure of the lungs of adult male albino rat.
Materials and Methods: 15 male rats were classified into: control group of 5 rats and sofosbuvir treated group of 10 rats that
received sofosbuvir orally in a dose of 4 mg/kg per day for 5 weeks. Blood samples were drawn to assess serum Transforming
growth factor- β (TGF-β). Lung specimens were obtained for evaluation by light microscope. Alpha smooth Muscle Actin
(α-SMA), E-cadherin immunohistochemistry, and statistical analysis were applied.
Results: Marked increase in the mean value of serum TGF-β in Sofosbuvir treated group when compared to control group.
Sofosbuvir resulted in histological and immunohistochemical changes in the lungs of sofosbuvir treated rats.
Conclusion: Severe lung injury was detected after treatment with sofosbuvir. However further studies should be done to
determine the exact mechanism and more caution should be taken during administration of sofosbuvir.

Keywords

Journal of Medical Histology
Volume 4, Issue 1
June 2020
Pages 119-125

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