Is there any possible role for telocytes in the pathogenesis of musculoskeletal diseases?

El Deeb, Ali; Abd El Hafez, Ahmed; Abd El Hafez, Amal

doi:10.21608/jmh.2021.54933.1088

Is there any possible role for telocytes in the pathogenesis of musculoskeletal diseases?

Document Type : Original Article

Authors

¹ Departments of Rheumatology Physical Medicine and Rehabilitation, Faculty of Medicine, Tanta University, Egypt

² Anesthesia And Pain Management, Faculty of Medicine, Tanta University, Egypt

³ Departments of Histology and Cell Biology, Faculty of Medicine, Tanta University, Egypt

10.21608/jmh.2021.54933.1088

Abstract

Background: Telocytes (Tc) are newly discovered histological cells that are scattered within most of the tissues and organs
including the musculoskeletal system. They are a peculiar type of interstitial cells with very long prolongations termed
telopodes (Tp). They have also been isolated and cultured from tissues in vitro.
Some recent researches have been done handling the possible physiological function of these cells and the pathophysiological
role in some musculoskeletal diseases. In any case, future functional studies of telocytes in vivo will help to understand the
mechanism by which telocytes contribute to tissue homeostasis in health and disease.
Aim: We are in need to highlight on these cells to widen the scope of research about the potential hidden roles of telocytes in
the pathogenesis of some rheumatic diseases.
Conclusion: Hence this review focuses on the latest progresses regarding Tc in the pathogenesis and/or repair and regeneration
of different tissues like skeletal muscle, synovium and peripheral nerves.

Keywords