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Journal of Medical Histology
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Volume Volume 5 (2021)
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mohammed, S., Abdel Aziz, H., awaad, A., mohamed, S. (2023). Gold Nanoparticles Alleviate Meloxicam Induced Toxicity in Adult Male Rat Spleen through Activation of Autophagy: Histological and Immunohistochemical Study.. Journal of Medical Histology, (), -. doi: 10.21608/jmh.2023.179541.1110
sherine Ahmed mohammed; hekmat osman Abdel Aziz; aziz awaad; samira mahmoud mohamed. "Gold Nanoparticles Alleviate Meloxicam Induced Toxicity in Adult Male Rat Spleen through Activation of Autophagy: Histological and Immunohistochemical Study.". Journal of Medical Histology, , , 2023, -. doi: 10.21608/jmh.2023.179541.1110
mohammed, S., Abdel Aziz, H., awaad, A., mohamed, S. (2023). 'Gold Nanoparticles Alleviate Meloxicam Induced Toxicity in Adult Male Rat Spleen through Activation of Autophagy: Histological and Immunohistochemical Study.', Journal of Medical Histology, (), pp. -. doi: 10.21608/jmh.2023.179541.1110
mohammed, S., Abdel Aziz, H., awaad, A., mohamed, S. Gold Nanoparticles Alleviate Meloxicam Induced Toxicity in Adult Male Rat Spleen through Activation of Autophagy: Histological and Immunohistochemical Study.. Journal of Medical Histology, 2023; (): -. doi: 10.21608/jmh.2023.179541.1110

Gold Nanoparticles Alleviate Meloxicam Induced Toxicity in Adult Male Rat Spleen through Activation of Autophagy: Histological and Immunohistochemical Study.

Articles in Press, Accepted Manuscript, Available Online from 17 January 2023  XML
Document Type: Original Article
DOI: 10.21608/jmh.2023.179541.1110
Authors
sherine Ahmed mohammed email orcid 1; hekmat osman Abdel Aziz2; aziz awaad3; samira mahmoud mohamed1
1department of histology, faculty of medicine, sohag university
2department of histology, faculty of medicine, sohag university.
3zoology department, faculty of science, sohag university
Abstract
Background: Meloxicam is an analgesic with higher selective inhibition of cyclooxygenase 2 (COX-2). COX-2 inhibition induces oxidative stress. Gold nanoparticles (AuNPs) have several medical applications in diagnosing and treating diseases and have potent free radical scavenging properties.
Objective: This study was conducted to assess the possible therapeutic effect of AuNPs on meloxicam-induced splenic toxicity at different time points.
Materials and methods: Forty-five rats were used in this experiment and were divided into eight groups: group I; the control group. Group II received AuNPs for 2 weeks. Groups III and IV received meloxicam for 2 weeks and 2 months respectively. Groups V and VI received AuNPs for 2 weeks after receiving meloxicam for 2 weeks and 2 months respectively. Groups VII and VIII received meloxicam for two weeks and 2 months respectively followed by cessation of treatment for 2 weeks. Both meloxicam and AuNPs were injected daily intraperitoneally in a dose of 15mg/kg and 50 ul respectively. Histological changes, AuNPs localization in the spleen by silver nitrate, PCNA immunoexpression to detect cellular proliferation, and LC3 and p62 for detecting autophagy activation were studied.
Results: Time-dependent degenerative histological changes and increased PCNA, LC3, and p62 expression were observed after meloxicam treatment. However, AuNPs ameliorated these changes.
Conclusion: AuNPs have a therapeutic role against the toxic effects of
meloxicam in the spleen which may be due to their antioxidant activity, in addition to activation of autophagy.
Keywords
AuNPs; meloxicam; autophagy
Main Subjects
IHC
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