The Possible Protective Role of Tannic Acid against Monosodium Glutamate-Induced Pancreatic and Liver Toxicity in Adult Male Albino Rats: Biochemical, Histological and Immunohistochemical Study

Document Type : Original Article

Authors

1 Departments of Histology, Faculty of Medicine, Sohag University, Sohag, Egypt.

2 Departments of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Sohag University, Sohag, Egypt.

Abstract

Background: Monosodium Glutamate (MSG) is a common flavor enhancer that has several toxic effects on different body
organs. Tannic acid (TA) is a naturally occurring antioxidant component with several pharmacological properties.
Objectives: The present study was conducted to assess the possible protective role of TA on MSG-induced hepatic and
pancreatic toxicity.
Materials and Methods: 40 adult male albino rats were divided into 4 equal groups. Group I was the control group, group II
received TA, group III received MSG, and group IV received TA + MSG for 4 weeks. TA and MSG were received in a dose
of 100mg/kg BW and 2g/kg BW respectively. At the end of the study, the evaluation was done by biochemical analysis and
histopathology. Immunohistochemistry was used to measure BAX antibody and insulin expression.
Results: MSG increased the levels of pancreatic enzymes; amylase and lipase enzymes, as well as blood sugar levels. Liver
enzymes were also increased. Histologically, degenerative changes were observed in the liver and pancreas with increased islets
surface area. MSG increased the expression of the apoptotic marker BAX and decreased β-cells percentage. Co-administration
of TA with MSG attenuated these degenerative effects.
Conclusion: MSG has toxic effects on the liver and pancreas leading to increased blood glucose levels. TA has an antioxidant
role against MSG toxicity with a reduction of blood glucose levels.

Keywords

Journal of Medical Histology
Volume 5, Issue 2
December 2021
Pages 171-187

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