sonbol, M., Elsawy, M., Desouky, A., Abdel Moaty, M. (2023). Role of Botulinum Toxin A (Botox) as a New Modality in Induced Rhematoid Arthritis Versus Corticosteroids in Adult Male Albino Rat. Journal of Medical Histology, 7(1), 65-78. doi: 10.21608/jmh.2022.151071.1102
Mohamed sonbol; Marwa M Elsawy; ahamed M Desouky; Mohamed Mohamed Abdel Moaty. "Role of Botulinum Toxin A (Botox) as a New Modality in Induced Rhematoid Arthritis Versus Corticosteroids in Adult Male Albino Rat". Journal of Medical Histology, 7, 1, 2023, 65-78. doi: 10.21608/jmh.2022.151071.1102
sonbol, M., Elsawy, M., Desouky, A., Abdel Moaty, M. (2023). 'Role of Botulinum Toxin A (Botox) as a New Modality in Induced Rhematoid Arthritis Versus Corticosteroids in Adult Male Albino Rat', Journal of Medical Histology, 7(1), pp. 65-78. doi: 10.21608/jmh.2022.151071.1102
sonbol, M., Elsawy, M., Desouky, A., Abdel Moaty, M. Role of Botulinum Toxin A (Botox) as a New Modality in Induced Rhematoid Arthritis Versus Corticosteroids in Adult Male Albino Rat. Journal of Medical Histology, 2023; 7(1): 65-78. doi: 10.21608/jmh.2022.151071.1102
Role of Botulinum Toxin A (Botox) as a New Modality in Induced Rhematoid Arthritis Versus Corticosteroids in Adult Male Albino Rat
1anatomy department, faculty of medicine, ain shams university
2anatomy department,faculty of medicine, ain shams university
3department of anatomy faculty of medicine Cairo University
Abstract
Introduction: Rheumatoid arthritis (RA) is defined as a chronic immune-mediated disease and the Botox is tried to be a new treatment. The aim of our work to compare the ameliorating actions of the peri-articular Botox as a new modality and the systematic corticosteroids on the rheumatoid arthritis in the adult albino rats. Materials and methods: Rats were randomly allocated into 5 weight-matched groups, each of 5 rats; Group 1: ten rats were divided into the negative control were left without any intervention and the positive control were injected intra-articularly with saline, Group 2 induced RA by injecting rats with Freund's Complete Adjuvant (CFA), Group 3 were injected with Botox together with CFA and Group 4 were injected with dexamethasone (DEX) with CFA. Results: the RA induced rats showed significant improvement histologically, biochemically and radiologically when given corticosteroids with mild amelioration when given Botox. Conclusion: we have concluded that the use of Botox and dexamethasone were effective therapies of the RA with the priority to dexamethasone in the management of the RA.