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Journal of Medical Histology
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Bayoumi, A., Yassa, H., Mohamed, R., El-sebaie, M., Mousa, A., Hassan, D. (2021). Nanocurcumin: A Promising Therapeutic Supplements Lessening Cadmium-Induced Lung Injury Of Adult Male Albino Rat. A Histopathological, Biochemical And Ultra-structural Study. Journal of Medical Histology, 5(1), 88-92. doi: 10.21608/jmh.2022.133055.1098
Ahmed Bayoumi; Hanan Yassa; Radwa Mohamed; Mohamed El-sebaie; Ali Mousa; Doaa Hassan. "Nanocurcumin: A Promising Therapeutic Supplements Lessening Cadmium-Induced Lung Injury Of Adult Male Albino Rat. A Histopathological, Biochemical And Ultra-structural Study". Journal of Medical Histology, 5, 1, 2021, 88-92. doi: 10.21608/jmh.2022.133055.1098
Bayoumi, A., Yassa, H., Mohamed, R., El-sebaie, M., Mousa, A., Hassan, D. (2021). 'Nanocurcumin: A Promising Therapeutic Supplements Lessening Cadmium-Induced Lung Injury Of Adult Male Albino Rat. A Histopathological, Biochemical And Ultra-structural Study', Journal of Medical Histology, 5(1), pp. 88-92. doi: 10.21608/jmh.2022.133055.1098
Bayoumi, A., Yassa, H., Mohamed, R., El-sebaie, M., Mousa, A., Hassan, D. Nanocurcumin: A Promising Therapeutic Supplements Lessening Cadmium-Induced Lung Injury Of Adult Male Albino Rat. A Histopathological, Biochemical And Ultra-structural Study. Journal of Medical Histology, 2021; 5(1): 88-92. doi: 10.21608/jmh.2022.133055.1098

Nanocurcumin: A Promising Therapeutic Supplements Lessening Cadmium-Induced Lung Injury Of Adult Male Albino Rat. A Histopathological, Biochemical And Ultra-structural Study

Article 7, Volume 5, Issue 1, June 2021, Page 88-92  XML PDF (1.1 MB)
Document Type: Original Article
DOI: 10.21608/jmh.2022.133055.1098
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Authors
Ahmed Bayoumi email orcid ; Hanan Yassa; Radwa Mohamed; Mohamed El-sebaie; Ali Mousa; Doaa Hassan
Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Egypt
Abstract
Background: Cadmium (Cd) is considered a health hazard due to its industrial use. Lungs and kidneys are the primary organs
affected by its toxicity. Inflammatory response in lung tissue is mediated by Cd exposure until it becomes dysfunctional. Cd
damages DNA indirectly by increasing reactive oxygen species generation, which interacts with DNA defense system leading
to genomic instability. Curcumin (C) has multiple health benefits, as well as its Nano-formulation, Nano-curcumin (NC),
which has potential to increase biological and pharmacological actions of curcumin.
Aim: To focus on Cd-mediated inflammatory response and cell apoptosis in lung tissue of adult male albino rat and use NC as
a potential therapeutic agent.
Methods and methods: Thirty adult albino male rats were split into three groups, each with ten rats: control (group I), Cd
treated (group II), and Cd+NC treated (group III). Rats were sacrificed and lungs were extracted for light microscopic and
ultra-structural examination. IL-6 and TNF-α concentration were estimated and lung cellular survival genes; Bax and Bcl2
expression was evaluated by PCR.
Results: Alveolar damage with loss of normal lung architecture were seen in H&E-stained sections of group II confirmed by
ultrastructural investigation revealing cellular cytoplasmic vacuolations with degenerated mitochondria. In group II, IL-6,
TNF-α and Bax gene were increased, whereas Bcl2 gene was decreased with increased Bax/Bcl-2 genes ratio expression.
NC treated group showed cellular restoration, decreased pro-inflammatory cytokines and decreased Bax/Bcl-2 genes ratio
expression.
Conclusions: NC can be taken as a medicinal supplement to ease Cd poisoning risk in lungs.
Keywords
Cadmium; Cell apoptosis; Lung; Nano-curcumin; Pro-inflammatory cytokines
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