AbdelHaleem, A., Ahmed, A., Ibrahim, R., EL Sheikh, S., Abdelzaher, W., Ali, A., Abdel Hafez, S. (2023). Possible Protective Effects of Quercetin versus Quercetin Loaded Chitosan Nanoparticles on Zinc Sulfate Induced Olfactory Mucosa and bulb Injury in Adult Male Albino Rats; Behavioral, Biochemical, Histological and immunohistochemical study. Journal of Medical Histology, 7(2), 185-218. doi: 10.21608/jmh.2024.297558.1130
Aliaa AbdelHaleem; Amira Ahmed; Randa Ibrahim; Sayed EL Sheikh; Walaa Abdelzaher; Azza` Ali; Sara Abdel Hafez. "Possible Protective Effects of Quercetin versus Quercetin Loaded Chitosan Nanoparticles on Zinc Sulfate Induced Olfactory Mucosa and bulb Injury in Adult Male Albino Rats; Behavioral, Biochemical, Histological and immunohistochemical study". Journal of Medical Histology, 7, 2, 2023, 185-218. doi: 10.21608/jmh.2024.297558.1130
AbdelHaleem, A., Ahmed, A., Ibrahim, R., EL Sheikh, S., Abdelzaher, W., Ali, A., Abdel Hafez, S. (2023). 'Possible Protective Effects of Quercetin versus Quercetin Loaded Chitosan Nanoparticles on Zinc Sulfate Induced Olfactory Mucosa and bulb Injury in Adult Male Albino Rats; Behavioral, Biochemical, Histological and immunohistochemical study', Journal of Medical Histology, 7(2), pp. 185-218. doi: 10.21608/jmh.2024.297558.1130
AbdelHaleem, A., Ahmed, A., Ibrahim, R., EL Sheikh, S., Abdelzaher, W., Ali, A., Abdel Hafez, S. Possible Protective Effects of Quercetin versus Quercetin Loaded Chitosan Nanoparticles on Zinc Sulfate Induced Olfactory Mucosa and bulb Injury in Adult Male Albino Rats; Behavioral, Biochemical, Histological and immunohistochemical study. Journal of Medical Histology, 2023; 7(2): 185-218. doi: 10.21608/jmh.2024.297558.1130
Possible Protective Effects of Quercetin versus Quercetin Loaded Chitosan Nanoparticles on Zinc Sulfate Induced Olfactory Mucosa and bulb Injury in Adult Male Albino Rats; Behavioral, Biochemical, Histological and immunohistochemical study
1Department of Histology and Cell BiologyوFaculty of Medicine, Minia University, Minia, Egypt
2Department of Anatomy and Embryology, Faculty of Medicine, Minia University, Minia, Egypt
3Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minia, Egypt
4Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minia, Egypt
Abstract
Background: Anosmia is a common annoying problem that affects quality of life. Nanoparticles act as nanocarriers that deliver potent drug payloads at a controlled rate at the target site. Purpose: This current work aimed to evaluate the potential preventive benefits of Quercetin (QU) versus Quercetin-loaded chitosan nanoparticles (QU-CSNPs) on an experimental rat model of anosmia and shed insight on its protective mechanisms. Methods: Forty rats were randomly divided into four groups, the Control group, the Zinc sulfate (ZnS) group, the ZnS+QU group, and the ZnS+QU-CSNPs group. Behavioral assessment was carried out. Olfactory mucosae and bulbs were collected for biochemical, histological, immunohistochemical, and morphometric analysis. Results: The ZnS group showed behavioral alternation, decreased glutathione levels, increased malonaldehyde, and tumor necrosis factor-α levels. Olfactory mucosa and bulb showed histological alterations, as well as a significant increase in COX- 2 immune-expression and decrease in PCNA and SOX2 expression. The ZnS+QU-CSNPs group showed amelioration in previously mentioned parameters and histological alternation than the ZnS+QU group. Conclusions: QU-CSNPs has prophylactic effects in an anosmia model than QU via its anti-inflammatory and antioxidant effects. This could pave the way for additional studies to investigate further mechanisms underlying the potential beneficial effects of QU-CSNPs and bring up a new line for anosmia therapy.
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