Askar, E., Selim, S., Sibai, H. (2019). Histological changes of human placenta in early intrauterine growth restriction with and without preeclampsia. Journal of Medical Histology, 3(1), 65-76. doi: 10.21608/jmh.2019.12648.1056
Eman Askar; Sally Selim; Hoda Sibai. "Histological changes of human placenta in early intrauterine growth restriction with and without preeclampsia". Journal of Medical Histology, 3, 1, 2019, 65-76. doi: 10.21608/jmh.2019.12648.1056
Askar, E., Selim, S., Sibai, H. (2019). 'Histological changes of human placenta in early intrauterine growth restriction with and without preeclampsia', Journal of Medical Histology, 3(1), pp. 65-76. doi: 10.21608/jmh.2019.12648.1056
Askar, E., Selim, S., Sibai, H. Histological changes of human placenta in early intrauterine growth restriction with and without preeclampsia. Journal of Medical Histology, 2019; 3(1): 65-76. doi: 10.21608/jmh.2019.12648.1056
Histological changes of human placenta in early intrauterine growth restriction with and without preeclampsia
1Department of Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
2Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Abstract
Background: Intra uterine growth restriction (IUGR) is a common pregnancy complication, pre-eclamsia (PE) is an important cause of this complication and is responsible for maternal and fetal morbidity and mortality. Idiopathic intrauterine growth restriction without obvious causes is not uncommon. Objective: The aim of this study is to examine the placental histology in both conditions trying to find specific criteria for each disorder. Materials and Methods: This study was conducted on three groups; group I was the control group, group II was preeclampsia induced IUGR (PE-IUGR) group and group III was idiopathic IUGR (I-IUGR). Each group contained 15 placentas. Placental specimens from each group were analyzed histopathologically and immunohistochemically. Results: we found that PE-IUGR and I-IUGR cases in this study share common histological changes suggesting a similar pathogenesis. Maternal mal-perfusion lesions predominated in PE-IUGR. Findings consistent with fetal vascular malperfusion were higher in I-IUGR. Hofbauer cells (HBC) were increased in both PE-IUGR and I-IUGR. Conclusion: abnormal utero-placental blood vessels and utero-placental insufficiency and the resulting histological changes in the chorionic villi, and chronic inflammatory lesions may be the primary disease processes related to the placental pathology of PE-IUGR and I-IUGR.
View on SCiNiTO
Top